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KMID : 0614720190620010011
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Journal of Korean Medical Association
2019 Volume.62 No. 1 p.11 ~ p.17
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Diagnosis and treatment of latent tuberculosis infection
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Min Jin-Soo
Kim Ju-Sang
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Abstract
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In order to eliminate tuberculosis worldwide by 2050, effective management of latent tuberculosis infection is essential, and policy-makers have begun to recognize the importance of scaling up preventive therapy. The current guideline recommends targeted latent tuberculosis infection testing that identifies high-risk groups based on risk stratification for progression from latent infection to active disease. Both the tuberculin skin test and interferon-gamma releasing assay have a similar diagnostic efficacy for predicting progression to active tuberculosis. The Korean guideline recommends 9-month isoniazid monotherapy as the standard treatment; however, more evidence supports that short course rifampicin-based regimen is both more effective and tolerable than isoniazid monotherapy
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KEYWORD
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Latent tuberculosis, Antituberculosis agent, Interferon-gamma release assay, Tuberculin skin test
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